Clinical Steering Committee
Dr. Steven Nissen, M.D.
Steven Nissen, MD, is the Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine located on the main campus of Cleveland Clinic. Prior to this, he served nine years as Vice-Chairman of the Department of Cardiology and five years as Medical Director of the
Dr. Nissen’s research during the last two decades has focused on the application of intravascular ultrasound (IVUS) imaging for the assessment of progression and regression of coronary atherosclerosis.
Contributions to scientific literature include approximately 270 journal articles with a respectable number of manuscripts in NEJM, Circulation, and JAMA, in addition to 60 book chapters and electronic publishings. In recent years, he has also written on the subject of drug safety and was the author of manuscripts highlighting concerns about the COX-2 inhibitors, muraglitazar and rosiglitazone.
Dr. Stephen J. Nicholls, MBBS, Ph.D.
Stephen J. Nicholls, MD, PhD, is the inaugural SAHMRI Heart Foundation Heart Disease Theme Leader at the South Australian Health & Medical Research Institute. Dr. Nicholls is also Professor of Cardiology at the University of Adelaide. He has authored more than 350 original manuscripts, meeting abstracts and book chapters. His current research interests include the functional properties of HDL, the role of inflammation and oxidative stress in atherogenesis and the development of new imaging modalities to assess factors that influence the natural history of atherosclerosis. He plays a lead role in clinical trials that employ intravascular ultrasound to investigate the impact of novel anti-atherosclerotic therapies.
Dr. Christie M. Ballantyne, M.D.
Dr. Ballantyne’s current positions include: Professor of Medicine, Baylor College of Medicine; Chief, Section of Atherosclerosis and Vascular Medicine; Director, The Maria and Alando J. Ballantyne, M.D., Atherosclerosis Clinical Research Laboratory; Director, Center for Cardiovascular Disease Prevention,
Dr. Ballantyne's clinical research is the prevention of atherosclerotic vascular disease. This interest includes pharmacological studies to assess the efficacy and benefits of lipid-lowering drug therapy including trials which utilize ultrasound and MRI to examine the effects of lipid-lowering drugs on the progression of atherosclerosis. As the director of The Maria and Alando J. Ballantyne, M.D., Atherosclerosis Clinical Research Laboratory, which serves as the core laboratory for the Atherosclerosis Risk in Communities study, Dr. Ballantyne is studying whether novel biomarkers might be useful in identifying individuals at high risk for cardiovascular disease, the metabolic syndrome and diabetes. Both genomics and proteomics are being used to identify novel molecules that are increased with atherosclerosis and the metabolic syndrome.
Dr. Philip Barter, MBBS, Ph.D., MRACP, FRACP
Dr. H. Bryan Brewer, M.D.
Dr. Brewer is currently Director, Washington Cardiovascular Associates, Senior Research Consultant, Lipoprotein and Atherosclerosis Research at the Cardiovascular Research Institute, a division of MedStar Research Institute, in Washington, DC. Prior to joining MedStar, Dr. Brewer was Chief of the Molecular Disease Branch at the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) in Bethesda, Maryland, a position he held from 1976 to 2005.
Dr. Brewer is a prominent researcher who has published more than 450 original manuscripts and 75 reviews and book chapters on the subjects of genetic dyslipoproteinemias, lipoprotein metabolism, and atherosclerosis. He was a member of the Board of the National Cholesterol Education Program, which established treatment guidelines for patients with hyperlipidemia in the United States, and has served on the editorial boards of several prestigious journals. He is curent on the editorial board of Clinical Lipidology. Dr. Brewer’s research led to the elucidation of the first published sequences for the human plasma apolipoproteins, the initial determination of the metabolism of the plasma apolipoproteins in normal and hyperlipidemic individuals, as well as the identification of multiple gene defects leading to the genetic dyslipoproteinemias. More recently, he has pioneered the use of transgenic mice and rabbits as well as recombinant adenovirus vectors to identify genes that modulate lipoprotein metabolism and the development of atherosclerosis. Dr. Brewer current focus is the development of methods to raise HDL for the treatment of high risk patients with cardiovascular disease.
A recipient of the JD Lane Investigator Award from the US Public Health Service, Dr. Brewer also received the Heinrich Wieland Prize from the Federal Republic of Germany and the Public Health Service Commendation Award, Meritorious & Service, Distinguished Service Medals from the NIH, George Lyman Duff Memorial Award Lecture, and the Robert I. Levy Award.
Dr. Brewer received his medical degree from Stanford University School of Medicine in California. After completing his internship and residency in internal medicine at Massachusetts General Hospital in Boston, Dr. Brewer joined the NHLBI.
Dr. John J.P. Kastelein, M.D., Ph.D.
Dr. John J.P. Kastelein, M.D., Ph.D., is Professor of Medicine and Chairman of the Department of Vascular Medicine at the Academic Medical Centre at the
He has published over 500 research papers in peer-reviewed journals and is an internationally recognized expert on the diagnosis and treatment of lipid and lipoprotein disorders, in particular, familial hypercholesterolemia, and research in the area of molecular biology of cholesterol transport.